HomeCoursesMEDSCI 204: Pharmacology and ToxicologyLecture 5 Lecture 5 1. What is the active ingredient in cannabis? d9-tetrahydrocannabinolWhat is the active ingredient in cannabis?== d9-tetrahydrocannabinol 2. How many phytocannabinoids are in cannabis? 110How many phytocannabinoids are in cannabis?== 110 3. How many compounds in cannabis in total? >400How many compounds in cannabis in total?== >400 4. What are the effects of cannabis? Euphoria, appetite, perceived increase in creativity, perceived increase in perception, drowsiness, short term memory loss, paranoia, rebound anxiety What are the effects of cannabis?== Euphoria, appetite, perceived increase in creativity, perceived increase in perception, drowsiness, short term memory loss, paranoia, rebound anxiety 5. Which GPCR do cannabinoids work on? CB1, CB2Which GPCR do cannabinoids work on? ==CB1, CB2 6. What are the endogenous cannabinoids called?= =Endocannabinoids What are the endogenous cannabinoids called?= =Endocannabinoids 7. What are the functions of endocannabinoids? Regulate other transmitters involved in memory, movement, painWhat are the functions of endocannabinoids?== Regulate other transmitters involved in memory, movement, pain 8. What are the concerns of cannabis use? Intoxication, phsychotic disorders, health, cognition, memory, immune suppressionWhat are the concerns of cannabis use?== Intoxication, phsychotic disorders, health, cognition, memory, immune suppression 9. What relation is THC to CB1? Partial agonist What relation is THC to CB1?== Partial agonist 10. What does partial agonism to CB1 do? Anti pain, anti vomiting, stimulates appetiteWhat does partial agonism to CB1 do?== Anti pain, anti vomiting, stimulates appetite 11. What does CBD do? Antagonise THC/endocannabinoidsWhat does CBD do?== Antagonise THC/endocannabinoids 12. What effects does CBD have? Anti pain, anti anxiety, anti seizureWhat effects does CBD have?== Anti pain, anti anxiety, anti seizure 13. What are the medicinal advantages of CBD? Pallative care, MS spasms, cancer, glaucoma, epilepsy, anxiety, auto immune diseasesWhat are the medicinal advantages of CBD?== Pallative care, MS spasms, cancer, glaucoma, epilepsy, anxiety, auto immune diseases 14. What are the issues with legalisation? Efficacy and safety not supported with RCTs, difficult regulation, contamination, inaccurate labelling, access for children, microbial toxinsWhat are the issues with legalisation?== Efficacy and safety not supported with RCTs, difficult regulation, contamination, inaccurate labelling, access for children, microbial toxins 15. What are the medicinal issues with cannabis? Concentrations, efficacy, detrimental effects, dosage, toxicity, drug interactionWhat are the medicinal issues with cannabis?== Concentrations, efficacy, detrimental effects, dosage, toxicity, drug interaction 16. What are the standards for medicinal cannabis? Max limit on contaminants, pesticides etc. Active ingredients, stability, labelling, acceptable dosage form (ie. vaping)What are the standards for medicinal cannabis?== Max limit on contaminants, pesticides etc. Active ingredients, stability, labelling, acceptable dosage form (ie. vaping) 17. What is Sativex? 1:1 purified THC:CBD for multiple sclerosisWhat is Sativex?== 1:1 purified THC:CBD for multiple sclerosis 18. What is Marinol? Synthetic THC for painWhat is Marinol?== Synthetic THC for pain 19. What is Epidiolex? Purified CBD for epilepsyWhat is Epidiolex?== Purified CBD for epilepsy 20. What cannabis clinical trials are recent?== Glioblastoma (80%), epilepsy (40%) 21. What problems are associated with synthetic cannabis? Cheap production, difficulty in legislating, full agonist, black marketWhat problems are associated with synthetic cannabis? ==Cheap production, difficulty in legislating, full agonist, black market 22. What are the negative effects of synthetic cannabinoids? Psychosis, cardiovascular arrest, deathWhat are the negative effects of synthetic cannabinoids?== Psychosis, cardiovascular arrest, death 23. How does affinity of synthetic cannabis compare to THC? SimilarHow does affinity of synthetic cannabis compare to THC?== Similar 24. How does response of synthetic cannabis compare with THC? More potentHow does response of synthetic cannabis compare with THC?== More potent Loading...
