HomeCoursesMEDSCI 204: Pharmacology and ToxicologyLecture 24 Lecture 24 1. What causes huntingtins disease? Expansion of CAG repeats (>36) in huntingtin gene. Mutant protein causes loss of GABAnerginc medium spiny neurons in striatumWhat causes huntingtins disease?== Expansion of CAG repeats (>36) in huntingtin gene. Mutant protein causes loss of GABAnerginc medium spiny neurons in striatum 2. What does loss of spiny neurons in striatum result in? Movement disorderWhat does loss of spiny neurons in striatum result in?== Movement disorder 3. What key hormone is needed for development and survival of medium spiny neurons? BDNFWhat key hormone is needed for development and survival of medium spiny neurons?== BDNF 4. How does mTHTT impair BDNF? Hungtingtin involved in vesicle transport -> mutant HTT impair BDNF transport to medium spiny neurons (MSNs)How does mTHTT impair BDNF?== Hungtingtin involved in vesicle transport -> mutant HTT impair BDNF transport to medium spiny neurons (MSNs) 5. What does loss of BDNF do to MSNs? Susceptible to excitotoxicityWhat does loss of BDNF do to MSNs?== Susceptible to excitotoxicity 6. What techniques are used to generate MSNs?== Induced neural precursor cells, AAV-BDNF delivery, transgenic rat 7. What was the problem with induced neural precursors? Developed HDWhat was the problem with induced neural precursors?== Developed HD 8. What was the result of AAV-BDNF? Decrease in neural loss, decrease in motor dysfunction, increase in neural loss w/o treatment, increase in motor dysfunction s/o treatmentWhat was the result of AAV-BDNF?== Decrease in neural loss, decrease in motor dysfunction, increase in neural loss w/o treatment, increase in motor dysfunction s/o treatment 9. What was the result of transgenic HD? Decrease in neural loss w/o treatment, decrease behaviour dysfunction, decrease neural loss with treatment, increase motor dysfunction w/o treatmentWhat was the result of transgenic HD?== Decrease in neural loss w/o treatment, decrease behaviour dysfunction, decrease neural loss with treatment, increase motor dysfunction w/o treatment Loading...
