Lecture 10

1.
What is clearance?
A constant that describes a drug concentration and elimination relationship
2.
How to calculate clearance?
Elimination rate/concentration or dose/area under the curve
3.
What does the elimination rate equal?
Clearance x concentration
4.
Why does elimination rate decrease?
Decrease in concentration
5.
What does the rate of elimination change equal?
Clearance
6.
What is clearance used for?
Calculating dose maintenance
7.
What is maintained target concentration called?
Steady state concentration
8.
How to calculate maintenance dose rate?
MD equals clearance x target conc.
9.
How to factor in bioavailability and oral dosing into MD?
Dose equals (clearance x steady state conc x dosing interval) / bioavailability
10.
What is half life of a drug?
The time it takes for drug concentration to fall to 50%
11.
What is the half life equation?
T(1/2) equals 0.7 x Vd / Clearance
12.
Is halflife related to concentration?
No
13.
How mych % is left after 4 half lives?
6.25%
14.
What causes accumulation?
Repeat doses given before concentration equals 0
15.
When is steady state concentration reached?
When dose rate equals elimination rate
16.
How many half lives to reach steady state?
4
17.
How many half lives to not accumulate?
5
18.
Can you reduce the time to reach steady state by increasing dose rate?
"No, as dose rate increases, so does steady state concentration"
19.
How can you shorten time to reach steady state concentration?
Through loading dose