HomeCoursesMEDSCI 204: Pharmacology and ToxicologyLecture 1 Lecture 1 1. What is pharmocodynamics? How drugs act upon the bodyWhat is pharmocodynamics?== How drugs act upon the body 2. What are the protein target categories? Receptors, Ion channels, Transporters, EnzymesWhat are the protein target categories?== Receptors, Ion channels, Transporters, Enzymes 3. What are the four steps to neurotransmission? Synthesis, release, action, inactivationWhat are the four steps to neurotransmission?== Synthesis, release, action, inactivation 4. What steps do drugs act upon? Synthesis, release, action, inactivationWhat steps do drugs act upon?== Synthesis, release, action, inactivation 5. Describe drug targets relating to the synthesis of acetyl choline? Choline transporter protein, choline acetyl transferaseDescribe drug targets relating to the synthesis of acetyl choline?== Choline transporter protein, choline acetyl transferase 6. What are the sites for drug action to inhibit release of acetylcholine? Calcium channels, vesicular monoamine transporter, presynaptic membraneWhat are the sites for drug action to inhibit release of acetylcholine?== Calcium channels, vesicular monoamine transporter, presynaptic membrane 7. What are the action drug targets? ReceptorsWhat are the action drug targets?== Receptors 8. What are the four families of receptors? Ligand gated ion channels, GPCRs, TKRs, steroid hormone receptorsWhat are the four families of receptors?== Ligand gated ion channels, GPCRs, TKRs, steroid hormone receptors 9. What is the magnitude of current flowing through an activated ion channel? 10^7 ions/sWhat is the magnitude of current flowing through an activated ion channel?== 10^7 ions/s 10. What are examples of ionotropic receptors (ligand gated ion channels) as drug targets? Nicotinic acetylcholine receptors, GABA receptors, glutamate receptorsWhat are examples of ionotropic receptors (ligand gated ion channels) as drug targets? ==Nicotinic acetylcholine receptors, GABA receptors, glutamate receptors 11. What acetycholine receptors have 5 subtypes? MuscarinicWhat acetycholine receptors have 5 subtypes?== Muscarinic 12. What pathway do the M2 and M4 muscarinic receptors mediate? Adenylate cyclase, RafWhat pathway do the M2 and M4 muscarinic receptors mediate?== Adenylate cyclase, Raf 13. What pathways do M1, M3, M5 muscarinic receptors mediate? Phosopholipase CWhat pathways do M1, M3, M5 muscarinic receptors mediate?== Phosopholipase C 14. What drugs target beta adrenoreceptors? PropanololWhat drugs target beta adrenoreceptors?== Propanolol 15. What drugs target adenosine receptors? caffeineWhat drugs target adenosine receptors?== caffeine 16. What drugs target dopamine receptors?== L-dopa 17. What drugs target opiod receptors?== Morphine, codeine 18. What drugs target seratonin receptors? LSDWhat drugs target seratonin receptors?== LSD 19. What drugs target muscarinic receptors? AtropineWhat drugs target muscarinic receptors?== Atropine 20. What drugs target cannabinoid receptors? CannibisWhat drugs target cannabinoid receptors?== Cannibis Loading...
