Lecture 27

1.
What is the virus behind glandular fever?
Epstein-barr virus
2.
Where do cold sores appear?
On the dentate line
3.
How is Herpes virus diagnosed?
Syndrome, immunofluoresence, PCR
4.
What is the treatment for herpes?
Acyclovir
5.
What is the long term result of Herpes?
Latent infection
6.
What virus causes cold sores?
Herpes simplex type 1
7.
What virus causes genital herpes?
Herpes simplex type II
8.
9.
What virus causes Kaposi's sarcoma?
Human herpes virus 8
10.
How is HVT1 transmitted?
Contact with saliva
11.
Where does HVT1 replicate?
Skin/oral membranes
12.
Where does latent HVT1 occur?
Trigeminal ganglion
13.
Which cells do HVT1 infect?
Epithelial => sensory neuron => epithelial
14.
When do latent reinfections occur?
Concurrently with other infections, stress
15.
What are sever complication of Herpes T1?= =Encephalitis, meningitis
16.
How is varicella zoster transmitted?
Contaminated skin/saliva
17.
Where does varicella zoster latency occur?
Dorsal root ganglion
18.
What does reactivation of varicella zoster virus create?
Shingles
19.
What activates shingles?
Lower immunity
20.
How is Epstein-Barr virus transmitted?
Infected saliva
21.
Where does EBV infection occure?
B lymphocytes => tonsils, lymph nodes
22.
What happens when the body fights infected B lymphcytes?
Swollen lymph nodes
23.
Where does latent infection of glandular fever occur?
B lymphocytes of saliva
24.
What can happen if immune system doesn't kill enough infected B lymphocytes?
Lymphomas
25.
How is EBV diagnosed?
Syndrome, PCR, Paul Bunnel test, B lymphocytes abnormal under microscope
26.
 is Paul Bunnel test?
Antibodies created after infection, stick to sheep RBCs (heterophile antibodies)
27.
What is used for treatment for HSV and VZV?
Acyclovir
28.
What is the treatment for EBV?
None