Lecture 17

1.
"During T cell activation, what is signal 1?
" Antigen engagement though TCR complex
2.
What is signal 2 during T cell activation?
Cytokines/hormones
3.
4.
What immune cells can MHCII only interact with?
CD 4
5.
What are the main co stimulating molecules?
B7, CD28
6.
Which cell expresses the CD 28 receptor?
T cell
7.
What cell expresses the B7 ligand?
APC cell
8.
What molecules are the B7 ligands?
CD 80, CD 86
9.
What causes expression of costimulatory signals?
DAMPs
10.
What happens when there are no co stiumlatory signals?
Anergy
11.
What is a signal 3 from an APC?
Cytokines released from APC
12.
In what ways do cytokines influence inflammation? (3)
Quality, amplitude, duration
13.
What are cytokines referred to as?
Interleukins
14.
Which cytokines are pro inflammatory?
IL-1, TNFÉ‘
15.
Which cytokine drives proliferation of B cells?
IL-4
16.
Which cytokine drives proliferation of T cells?
IL-2
17.
Which cytokine drives proliferaton of neutrophils?
G-CSF
18.
Which cytokine drives proliferation of monocytes?
M-CSF