Lecture 1

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Question 1 of 21

What is histology? = Histos: tissues, ology: the study of

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Question 2 of 21

What is tissue made up of? (2) = Cellular elements, Extracellular matrix

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Question 3 of 21

What is the ECM made up of? (2) = Fibres, non fibrous component

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Question 4 of 21

What is the non fibrous component made up of? (3) = Glycosaminoglycans, glycoproteins, proteoglycans

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Question 5 of 21

What are glycosaminoglycans made up of? = Polysaccharides (chains of repeating disaccharide units)

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Question 6 of 21

What do GAGs do? (3) = Attract H20, connect to collagen, connect to proteins to form glycoproteins

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Question 7 of 21

What are glycoproteins made of? (2) = Proteins + oligosaccharides

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Question 8 of 21

What are glycoproteins important for? (2) = Cell-ECM/integrin attachment, development 

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Question 9 of 21

What charge do GAGs have? = Negative

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Question 10 of 21

What charge to glycoproteins have? = Negative

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Question 11 of 21

What are proteoglycans made of? (2) = Proteins + GAGs

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What are some examples of GAGs? (4) = Hyaluronic acid , Keratan sulfate , Heparan sulfate , Chondroitin 4-sulfate

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Question 13 of 21

What are some examples of glycoproteins? (4) = Laminin, fibronectin, chondronectin, osteonectin

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Question 14 of 21

What are some examples of proteoglycans? (3) = Decorin (needed to form collagen fibres) , Aggrecan , Syndecan

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Question 15 of 21

What are the types of fibres in the ECM? = Collagen, reticular, elastic

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Question 16 of 21

What % of body proteins are collagen? = 25-35%

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Question 17 of 21

What are the types of collagen? (4) = Fibril associated, fibril forming, network forming, membrane bound

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Question 18 of 21

Which fibres of the ECM are made of collagen? = (2) Collagen, reticular

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Question 19 of 21

What are integrins? = Cell adhesion receptors or transmembrane proteins

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Question 20 of 21

What do integrins do? (2) = Attach cells to ECM, Cell communication

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Question 21 of 21

Which glycoproteins (as ligands) bind to integrins? (2) = Fibronectin, laminin

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