HomeCoursesMEDSCI 204: Pharmacology and ToxicologyLecture 11 Lecture 11 1. What are the types of adverse drug reactions? Pre approval, post approval, side effectWhat are the types of adverse drug reactions?== Pre approval, post approval, side effect 2. What is an adverse drug event as opposed to an adverse drug reaction? An adverse occurance which may or may not have a causal relationship to a drugWhat is an adverse drug event as opposed to an adverse drug reaction?== An adverse occurance which may or may not have a causal relationship to a drug 3. What is the leading cause of medical injury? ADRs (20% of morbidity/mortality)What is the leading cause of medical injury? ==ADRs (20% of morbidity/mortality) 4. How many hospital admissions are a result of ADRs? 5%How many hospital admissions are a result of ADRs?== 5% 5. What are the 3 most dangerous drugs? Opiods, anticoagulants, antibioticsWhat are the 3 most dangerous drugs?== Opiods, anticoagulants, antibiotics 6. What are classifications of ADR? Augmented, bizarre, chemical, delayed, end of treatment (withdrawl)What are classifications of ADR?== Augmented, bizarre, chemical, delayed, end of treatment (withdrawl) 7. What is a serious ADR? An event/outcome that could cause morbidity or mortalityWhat is a serious ADR?== An event/outcome that could cause morbidity or mortality 8. What is a severe ADR? Intense but not life threateningWhat is a severe ADR?== Intense but not life threatening 9. w to evaluate toxic mechanisms? Mechanistic studiesw to evaluate toxic mechanisms?== Mechanistic studies 10. How can metabolism influence ADRs? Clearance altered can cause toxicity, metabolites can cause toxicityHow can metabolism influence ADRs?== Clearance altered can cause toxicity, metabolites can cause toxicity 11. Why is fentanyl more dangerous than heroine? 1000x more potentWhy is fentanyl more dangerous than heroine? ==1000x more potent 12. Which organs does paracetamol affect? LiverWhich organs does paracetamol affect?== Liver 13. Which organs does aspirin affect? multi organ/GI tractWhich organs does aspirin affect?== multi organ/GI tract 14. Which organs does ibuprofen affect? KidneysWhich organs does ibuprofen affect?== Kidneys 15. What are the features of aspirin toxicity? Chemical insult followed by pharmocological effectWhat are the features of aspirin toxicity?== Chemical insult followed by pharmocological effect 16. How does ibuprofen affect kidneys? Inhibits protoglandinsHow does ibuprofen affect kidneys? ==Inhibits protoglandins 17. What are the risk factors for NSAID induced kidney injury? Age, pre existing renal disease, low blood volume, medications (ACE inhibitors, ang II R blockers)What are the risk factors for NSAID induced kidney injury?== Age, pre existing renal disease, low blood volume, medications (ACE inhibitors, ang II R blockers) 18. How does penecillinb cause ADRs? Allergy/anaphylaxisHow does penecillinb cause ADRs?== Allergy/anaphylaxis 19. Why do ADRs not show up in RCTs during development? Long term usage, dosage increase, interactionsWhy do ADRs not show up in RCTs during development?== Long term usage, dosage increase, interactions Loading...
